Translational control and cancer therapy
نویسندگان
چکیده
منابع مشابه
Gene therapy and translational cancer research.
Chi V. Dang, Stanton L. Gerson, Marcia Litwak, and Martin Padarathsingh Department of Medicine and The Johns Hopkins Oncology Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 [C. V. D.]; Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 [S. L. G.]; and the Center for Scientific Review, NIH, Bethesda, Maryland 20817 [M...
متن کاملTranslational control in cancer etiology.
The link between perturbations in translational control and cancer etiology is becoming a primary focus in cancer research. It has now been established that genetic alterations in several components of the translational apparatus underlie spontaneous cancers as well as an entire class of inherited syndromes known as "ribosomopathies" associated with increased cancer susceptibility. These discov...
متن کاملTranslational Approaches towards Cancer Gene Therapy: Hurdles and Hopes.
INTRODUCTION Of the cancer gene therapy approaches, gene silencing, suicide/apoptosis inducing gene therapy, immunogene therapy and targeted gene therapy are deemed to sub-stantially control the biological consequences of genomic changes in cancerous cells. Thus, a large number of clinical trials have been conducted against various malignancies. In this review, we will discuss recent translatio...
متن کاملMicroRNAs: Critical Regulators of mRNA Traffic and Translational Control with Promising Biotech and Therapeutic Applications
Context:MicroRNAs (miRNAs) are a class of short, endogenously-initiated, non-coding RNAs that post-transcriptionally control gene expression via translational repression or mRNA turnover. MiRNAs have attracted much attention in recent years as they play critical roles in gene expression and are promising tools with many biotech and therapeutic applications. The molecular mechanisms und...
متن کاملWhat can rheumatologists learn from translational cancer therapy?
It is well established that an intimate connection exists between inflammation and neoplasia. Indeed, particular chronic infections and autoimmune processes giving rise to prolonged site-specific inflammation are known to increase the probability of the development of specific cancers. Molecular characterisation of these processes has revealed profound similarities in the specific molecules inv...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cell Cycle
سال: 2008
ISSN: 1538-4101,1551-4005
DOI: 10.4161/cc.7.18.6683